B6-hBCMA (hTNFRSF17)
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Age
Genotype
Sex
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Basic Information
Model Name
B6-hBCMA (hTNFRSF17)
Product ID
C001630
Gene Name
Background
C57BL/6NCya
Gene Alias
BCM; BCMA; CD269; TNFRSF13A
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
16
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Note: When using this mouse strain in a publication, please cite “B6-hBCMA (hTNFRSF17) mice (Catalog C001630) were purchased from Cyagen.”
Strain Description
The B6-hBCMA (TNFRSF17) mouse is a humanized model constructed using gene editing technology, where the mouse BCMA endogenous extracellular domain (aa.1~49) was replaced with the human BCMA extracellular domain (aa.1~54). Homozygous B6-hBCMA (TNFRSF17) mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of multiple myeloma, systemic lupus erythematosus and various B cell-related diseases and for the development of BCMA-targeted drugs.
Application Area
BCMA-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of multiple myeloma, systemic lupus erythematosus and various B cell-related diseases
Validation Data