B6-hFGFR1c
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hFGFR1c
Product ID
C001684
Gene Name
Background
C57BL/6NCya
Gene Alias
CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1
Classification
Tumor Target Humanized Models,Metabolic Target Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
--
Chromosome
8
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Note: When using this mouse strain in a publication, please cite “B6-hFGFR1c mice (Catalog C001684) were purchased from Cyagen.”
Strain Description
B6-hFGFR1c mice are humanized models generated by gene editing technology, in which the p.22R to partial intron 2 of the mouse Fgfr1 gene was replaced in situ with p.22R to 376E from the coding sequence of the human FGFR1 gene, p.377I to 823X from the coding sequence of the mouse Fgfr1 gene, and the 3'UTR of the mouse Fgfr1 gene. This model can be used to study the pathological mechanisms and therapeutic methods of cancers, metabolic diseases such as obesity, diabetes, and metabolic-associated steatohepatitis (MASH), as well as the screening and development of FGFR1c-targeted drugs, and preclinical efficacy and safety evaluations.
Application Area
Screening, development, and preclinical efficacy evaluation of FGFR1c-targeted drugs
Study of pathological mechanisms and therapeutic methods for cancers and metabolic diseases such as obesity, diabetes, and metabolic-associated steatohepatitis (MASH)
Validation Data