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B6-h4-1BB/hPDL1
Product ID:
C001686
Background:
C57BL/6N;6JCya
Documents:
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Basic Information
Model Name
B6-h4-1BB/hPDL1
Product ID
C001686
Gene Name
TNFRSF9, CD274
Background
C57BL/6N;6JCya
Gene Alias
ILA; 4-1BB; CD137; CDw137; IMD109; B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
3604, 29126
Phenotype
MGI:1101059, MGI:1926446
Chromosome
--
More
Rare Disease Data Center >>
Document
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Note
Note: When using this mouse strain in a publication, please cite “B6-h4-1BB/hPDL1 mice (Catalog C001686) were purchased from Cyagen.”
Strain Description
B6-h4-1BB/hPDL1 mice are TNFRSF9 and CD274 double humanized mouse models obtained by mating TNFRSF9 humanized mouse models (Catalog No. C001604) with CD274 humanized mouse models (Catalog No. C001235). They express human TNFRSF9 and CD274 genomic sequences under the control of mouse promoters. This model is a valuable tool for studying cancer immunotherapy. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting TNFRSF9 and CD274.
Application Area
Area
4-1BB/PD-L1-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of cancer immunotherapy
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