B6-H11-hBDCA2 (hCLEC4C)
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-H11-hBDCA2 (hCLEC4C)
Product ID
C001693
Gene Name
Background
C57BL/6NCya
Gene Alias
DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150
Classification
Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
12
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Note: When using this mouse strain in a publication, please cite “B6-H11-hBDCA2 (hCLEC4C) mice (Catalog C001693) were purchased from Cyagen.”
Strain Description
B6-H11-hCLEC4C mice are humanized models generated by gene editing technology, in which the human CLEC4C genomic DNA was inserted at the H11 safe harbor. This modification does not affect the expression of the mouse homologous gene Clec4b1. This model can be used to study the pathological mechanisms and therapeutic methods of autoimmune disorders and hematological malignancies, as well as the screening and development of CLEC4C-targeted drugs, and preclinical efficacy and safety evaluations.
Application Area
Screening, development, and preclinical efficacy evaluation of CLEC4C-targeted drugs
Study of pathological mechanisms and therapeutic methods for autoimmune disorders
Study of pathological mechanisms and therapeutic methods for hematological malignancies
Validation Data