B6-hB2M & HLA-A2.1/mB2m KO
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hB2M & HLA-A2.1/mB2m KO
Product ID
C001696
Background
C57BL/6N;6JCya
Gene Alias
IMD43; AMYLD6; MHC1D4; HLAA; Ly-m11; beta2m; beta2-m
Classification
Other Target Humanized Models,Autoimmune Disease Models
Phenotype
--
Chromosome
15
Document
Note: When using this mouse strain in a publication, please cite “B6-hB2M & HLA-A2.1/mB2m KO mice (Catalog C001696) were purchased from Cyagen.”
Strain Description
The B6-hB2M&HLA-A2.1/mB2m KO mice are a humanized model obtained by mating H11-hB2M&HLA-A2.1 mice (Catalog Number: I001138) with B2m gene knockout mouse model (Catalog Number: S-KO-19919). While knocking out the mouse B2m gene, the chimeric H2-K1 HLA-A2.1 gene is integrated into the H11 safe harbor locus, which may be able to recapitulate the immune response of the human HLA-A*0201 (MHCI) subtype. This model can play an important role in studying the determinants of HLA-A2.1-restricted cytotoxic T lymphocytes (CTLs) and the development of potential viral vaccines and helps research the human immune response to a variety of antigens.
Application Area
Development and testing of novel viral vaccines
Testing of drug and vaccine safety and immunogenicity
Research on oncology and autoimmune diseases
Research on the interaction mechanism between human immune cells and pathogens
Research on allogeneic tumor transplantation
Validation Data