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NKG-hFcRn
Product ID:
C001706
Background:
NKG
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Strain Description
The NKG-hFcRn mouse is a humanized model constructed by replacing the exon 2 coding region plus partial intron 2 of the mouse Fcgrt gene in situ with the "Human FCGRT CDS-3'UTR of Mouse Fcgrt-WPRE-BGH pA" cassette. It expresses human FcRn to replace the endogenous mouse FcRn. The homozygous NKG-hFcRn mice are viable and fertile. This model may help evaluate the pharmacokinetics/pharmacodynamics of human immunoglobulin G in transplantation research, human tumor xenografts, and mouse tumor allografts.
Application Area
Area
In vivo transport, maintenance, and metabolism studies of IgG
Area
Development and screening of IgG antibody drug candidates
Area
Pharmacology, Pharmacodynamics, and Pharmacokinetics of IgG antibody drugs
Area
Evaluation of Fc-based immunotherapy
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