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NKG-hFcRn
Product ID:
C001706
Background:
NKG
Documents:
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Basic Information
Model Name
NKG-hFcRn
Product ID
C001706
Gene Name
Il2rg, FCGRT
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c); FCRN; FcgammaRn; alpha-chain
Classification
Immunodeficient Mouse Models
NCBI ID
16186, 2217
Phenotype
MGI:96551, MGI:103017
Chromosome
--
More
Rare Disease Data Center >>
Document
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Note
Note: When using this mouse strain in a publication, please cite “NKG-hFcRn mice (Catalog C001706) were purchased from Cyagen.”
Strain Description
The NKG-hFcRn mouse is a humanized model constructed by replacing the exon 2 coding region plus partial intron 2 of the mouse Fcgrt gene in situ with the "Human FCGRT CDS-3'UTR of Mouse Fcgrt-WPRE-BGH pA" cassette. It expresses human FcRn to replace the endogenous mouse FcRn. The homozygous NKG-hFcRn mice are viable and fertile. This model may help evaluate the pharmacokinetics/pharmacodynamics of human immunoglobulin G in transplantation research, human tumor xenografts, and mouse tumor allografts.
Application Area
Area
In vivo transport, maintenance, and metabolism studies of IgG
Area
Development and screening of IgG antibody drug candidates
Area
Pharmacology, Pharmacodynamics, and Pharmacokinetics of IgG antibody drugs
Area
Evaluation of Fc-based immunotherapy
Validation Data
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