B6-hALK7 (hACVR1C)
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Basic Information
Model Name
B6-hALK7 (hACVR1C)
Product ID
C001709
Gene Name
Background
C57BL/6NCya
Gene Alias
ALK7; ACVRLK7
Classification
Metabolic Target Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hALK7 (hACVR1C) mice (Catalog C001709) were purchased from Cyagen.”
Strain Description
The B6-hALK7 (hACVR1C) mouse is a humanized model constructed using gene editing technology, where the region from aa.27 in exon 2 to partial intron 2 of mouse Acvr1c was replaced with "ACVR1C chimeric CDS-WPRE-BGH pA" cassette. The murine signal peptide (aa.1~25) of Acvr1c was preserved. This model can be used for studying the pathological mechanisms and therapeutic approaches of metabolic disorders such as obesity and type 2 diabetes, and certain cancers like retinoblastoma, and for the development of ACVR1C-targeted drugs.
Application Area
ACVR1C-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of metabolic disorders such as obesity and type 2 diabetes
Research on the pathological mechanisms and therapeutic approaches of certain cancers like retinoblastoma
Validation Data