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Sim1-iCre
Product ID:
C001763
Background:
C57BL/6JCya
Documents:
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Expressing Tissues/Cells:
Paraventricular nucleus of the hypothalamus, supraoptic nucleus, preoptic periventricular area, amygdala, hippocampus, and Sim1-positive cells
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Strain Description
Sim1-iCre mice are generated by knocking an IRES-iCre cassette downstream of the TGA stop codon in the mouse Sim1 gene via genome editing, enabling iCre recombinase (codon-optimized Cre) expression driven by endogenous Sim1 regulatory elements. The expression pattern of iCre recombinase mirrors that of the endogenous Sim1 gene. When crossed with mice containing loxP sites, Cre-mediated recombination between loxP sites is expected to occur in Sim1-positive cells of the offspring.
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