B6-hCD40/hCD40LG
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Basic Information
Model Name
B6-hCD40/hCD40LG
Product ID
C001781
Background
C57BL/6NCya
Gene Alias
p50; Bp50; CDW40; TNFRSF5; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
Classification
Immune Target Humanized Models,Autoimmune Disease Models
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hCD40/hCD40LG mice (Catalog C001781) were purchased from Cyagen.”
Strain Description
The B6-hCD40/hCD40LG mouse is a dual-gene humanized model (for CD40 and CD40LG) generated by crossing B6-hCD40 mice (Catalog No.: C001721) with B6-hCD40LG mice (Catalog No.: C001720). The B6-hCD40/hCD40LG mouse model can be used for research on the mechanisms and therapeutic approaches of diseases such as autoimmune diseases, cancer, and cardiovascular diseases, as well as for the development of CD40/CD40L-targeted drugs.
Application Area
Screening, development, and preclinical evaluation of CD40/CD40L-targeted drugs
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases such as systemic lupus erythematosus (SLE) and lupus nephritis (LN)
Research on various malignant tumors
Research on cardiovascular diseases and neurological diseases
Validation Data