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B6-hFAP
Product ID:
C001783
Background:
C57BL/6NCya
Documents:
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Basic Information
Model Name
B6-hFAP
Product ID
C001783
Gene Name
FAP
Background
C57BL/6NCya
Gene Alias
FAPA; SIMP; DPPIV; FAPalpha
Classification
Tumor Target Humanized Models
NCBI ID
2191
Phenotype
MGI:109608
Chromosome
2
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Rare Disease Data Center >>
Document
Click here to download >>
Note
Note: When using this mouse strain in a publication, please cite “B6-hFAP mice (Catalog C001783) were purchased from Cyagen.”
Strain Description
The B6-hFAP mouse is a humanized model constructed by replacing the sequence from ATG start codon to partial intron 2 of the mouse Fap gene with the Kozak Human FAP CDS-3'UTR of Mouse Fap-WPRE-BGH pA cassette. B6-hFAP mice can be used for research into the pathogenesis of various malignant tumors, as well as for the screening, development, and safety evaluation of FAP-targeted drugs.
Application Area
Area
FAP-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of malignant tumors
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