B6-hIL1B
Product Type
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Genotype
Sex
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Basic Information
Model Name
B6-hIL1B
Product ID
C001791
Gene Name
Background
C57BL/6NCya
Gene Alias
IL-1; IL1F2; IL1beta; IL1-BETA
Classification
Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hIL1B mice (Catalog C001791) were purchased from Cyagen.”
Strain Description
The B6-hIL1B mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il1b gene with the coding sequences of the human IL1B gene. B6-hIL1B mice can be used for research into the pathogenesis of various inflammatory diseases, autoimmune diseases, cancers, and neurodegenerative diseases, as well as for the screening, development, and safety evaluation of IL1B-targeted drugs.
Application Area
IL1B-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of gout, rheumatoid arthritis (RA), recurrent pericarditis, type 2 diabetes (T2D), and other inflammatory and autoimmune diseases
Research on the pathological mechanisms and therapeutic approaches of cancers
Research on the pathological mechanisms and therapeutic approaches of neurodegenerative diseases
Validation Data