B6-hα4β7/hTL1A
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hα4β7/hTL1A
Product ID
C001795
Background
C57BL/6Cya
Gene Alias
IA4; CD49D; TL1; TL1A; VEGI; TNLG1B; VEGI192A
Classification
Immune Target Humanized Models,Cytokine Humanized Models,Autoimmune Disease Models
Phenotype
Chromosome
--
Document
Note: When using this mouse strain in a publication, please cite “B6-hα4β7/hTL1A mice (Catalog C001795) were purchased from Cyagen.”
Strain Description
B6-hα4β7/hTL1A mouse is a triple-gene humanized model for ITGA4, ITGB7, and TNFSF15, generated by crossing B6-hα4β7 mice (Catalog No.: C001689) with B6-hTL1A (TNFSF15) mice (Catalog No.: C001603). This model serves as a valuable tool for researching immune-related diseases, applicable to studies on T cell differentiation and survival, immune response regulation, and autoimmune diseases. It provides a robust preclinical research platform for the screening, development, and safety evaluation of α4β7/TL1A-targeted drugs.
Application Area
Screening, development, and preclinical evaluation of drugs targeting α4β7 integrin and TNFSF15
Research on the pathological mechanisms and therapeutic approaches of inflammatory diseases and autoimmune diseases
Research on T cell differentiation and survival
Research on immune response regulation
Validation Data