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B6-hHAVCR2
Product ID:
C001800
Background:
C57BL/6JCya
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Strain Description
The B6-hHAVCR2 mouse is a humanized model, constructed by replacing the mouse Havcr2 endogenous signal peptide (aa.1-19) and extracellular domain (aa.20-193) with the human HAVCR2 signal peptide (aa.1-21) and extracellular domain (aa.22-202). The murine transmembrane-cytoplasmic region (aa.194~281) is preserved. B6-hHAVCR2 mice can be used for research into the pathogenesis of various inflammatory diseases and cancers. They are also useful for the screening, development, and safety evaluation of HAVCR2-targeted drugs.
Application Area
Area
HAVCR2-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of various inflammatory diseases and cancers
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