B6-hIL2
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hIL2
Product ID
C001804
Gene Name
Background
C57BL/6NCya
Gene Alias
IL-2; TCGF; lymphokine
Classification
Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hIL2 mice (Catalog C001804) were purchased from Cyagen.”
Strain Description
The B6-hIL2 mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il2 gene with the coding sequences of the human IL2 gene. B6-hIL2 mice can be used for research into the pathogenesis of autoimmune disorders like systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis, Sjögren's syndrome, multiple sclerosis, and type 1 diabetes, as well as for the screening, development, and safety evaluation of IL2-targeted drugs.
Application Area
IL2-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of certain cancers
Research on the pathological mechanisms and therapeutic approaches of autoimmune disorders, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis, Sjögren's syndrome, multiple sclerosis, and type 1 diabetes
Validation Data