B6-hC5
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hC5
Product ID
C001824
Gene Name
Background
C57BL/6JCya
Gene Alias
C5D; C5a; C5b; ECLZB; CPAMD4
Classification
Cytokine Humanized Models,Full-Gene Humanized Models,Ophthalmic Disease Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
9
Document
Note: When using this mouse strain in a publication, please cite “B6-hC5 mice (Catalog C001824) were purchased from Cyagen.”
Strain Description
The B6-hC5 mouse model is a humanized model of the Hc gene, with the mouse Hc gene homologous to the human C5 gene. Using gene-editing technology, the mouse Hc gene was replaced with the human C5 gene while retaining the mouse signal peptide; the humanized region also includes the 3’ UTR. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate mutation models based on this strain and provide customized services.
Application Area
Preclinical research on C5-targeted drugs
Research in immunotherapy, oncology, etc.
Validation Data