Trex1 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Trex1 KO
Product ID
C001825
Gene Name
Background
C57BL/6JCya
Gene Alias
--
Classification
Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
9
Document
Note: When using this mouse strain in a publication, please cite “Trex1 KO mice (Catalog C001825) were purchased from Cyagen.”
Strain Description
The Trex1 KO mouse is a knockout (KO) model in which the protein-coding sequence of the Trex1 gene (homologous to the human TREX1 gene) has been deleted via gene-editing technology. Preliminary validation data indicate that homozygous Trex1 KO mice typically die of myocarditis at 3–4 months of age. Although some 3-month-old homozygotes are fertile, most exhibit premature weakness and are unable to breed. This model can be used to study the pathogenic mechanisms of diseases such as Aicardi-Goutières syndrome (AGS), systemic lupus erythematosus (SLE), familial chilblain lupus (FCL), and retinal vasculopathy with cerebral leukodystrophy (RVCL), and to provide a basis for developing related therapeutic strategies.
Application Area
Research on Aicardi-Goutières syndrome (AGS)
Research on systemic lupus erythematosus (SLE)
Research on familial chilblain lupus (FCL)
Research on retinal vasculopathy with cerebral leukodystrophy (RVCL)
Validation Data