B6-Mmut*M698K/Mmut KO
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Basic Information
Model Name
B6-Mmut*M698K/Mmut KO
Product ID
C001828
Gene Name
Background
C57BL/6JCya
Gene Alias
Mcm; Mut; D230010K02Rik
Classification
Metabolic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-Mmut*M698K/Mmut KO mice (Catalog C001828) were purchased from Cyagen.”
Strain Description
B6-Mmut*M698K/Mmut KO mice are a MMA disease model generated by crossing Mmut-knockout mice (with exon 3 deleted) with Mmut-mutant mice (carrying the p.M698K mutation in exon 12). Homozygous deletion of the gene results in embryonic lethality, and homozygous mutant mice die within 1 day of birth. The p.M698K (ATG to AAG) mutation carried by B6-Mmut*M698K/Mmut KO mice is equivalent to the p.M700K (ATG to AAG) mutation in the human MMUT gene. This model can be used to study the pathogenic mechanisms and therapeutic approaches for MMA.
Application Area
Research on the pathogenic mechanisms and therapeutic approaches of methylmalonic acidemia (MMA)
Research on the mechanisms of other mitochondrial metabolic diseases
Research on the mechanisms of neurological damage
Research on the mechanisms and therapeutic strategies of kidney diseases
Validation Data