SD-huNPR1
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
SD-huNPR1
Product ID
CR010
Gene Name
Background
Sprague-Dawley
Gene Alias
ANPa; NPRA; ANPRA; GUC2A; GUCY2A
Classification
Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “SD-huNPR1 mice (Catalog CR010) were purchased from Cyagen.”
Strain Description
SD-huNPR1 rats are a humanized model generated using gene editing technology, in which the rat Npr1 endogenous extracellular domain (aa.29~469) is replaced with the human NPR1 extracellular domain (aa.33~473). SD-huNPR1 rats can be used for studying the pathological mechanisms and therapeutic approaches for several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease, as well as specific cancers. They are also useful for the development of NPR1-targeted drugs.
Application Area
NPR1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease
Research on the pathological mechanisms and therapeutic approaches of specific cancers
Validation Data