FVB-hHTT Q150 KI
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
FVB-hHTT Q150 KI
Product ID
I001019
Gene Name
Background
FVB/NJCya
Gene Alias
HD; IT15; LOMARS
Classification
Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
4
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Note: When using this mouse strain in a publication, please cite “FVB-hHTT Q150 KI mice (Catalog I001019) were purchased from Cyagen.”
Strain Description
This strain is an hHTT Q150 knock-in mouse model generated by gene editing technology, in which a mutated human HTT gene sequence carrying 150 CAG repeats is inserted into the mouse genome. Literature reports have shown that these mice exhibit pathological features and functional impairments characteristic of Huntington's disease, and are suitable for developing and screening therapeutic drugs for Huntington's disease and safety evaluation. The heterozygous FVB-hHTT Q150 KI mice are viable and fertile.
Application Area
Development and screening of therapeutic drugs for Huntington's disease
Evaluation of therapeutic drug efficacy and safety for Huntington's disease
Research on the pathogenesis of Huntington's disease
Validation Data