Abca4 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Abca4 KO
Product ID
I001134
Gene Name
Background
C57BL/6JCya
Gene Alias
RmP; Abcr; Abc10; D430003I15Rik
Classification
Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “Abca4 KO mice (Catalog I001134) were purchased from Cyagen.”
Strain Description
This strain is an Abca4 gene knockout (KO) mouse model. Gene-editing technology was used to delete the protein-coding sequence of the Abca4 gene (the homolog of the human ABCA4 gene) in mice. Previous studies have demonstrated that Abca4 KO mice exhibit delayed dark adaptation following photobleaching and a slow progression of photoreceptor degeneration. Homozygous Abca4 KO mice are viable and fertile.
Application Area
Research on Stargardt Disease (STGD)
Research on Cone-rod Dystrophy (CRD)
Research on Retinitis Pigmentosa (RP)
Validation Data