B6-hC3
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hC3
Product ID
I001135
Gene Name
Background
C57BL/6JCya
Gene Alias
ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p
Classification
Cytokine Humanized Models,Full-Gene Humanized Models,Ophthalmic Disease Models,Autoimmune Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
19
Document
Note: When using this mouse strain in a publication, please cite “B6-hC3 mice (Catalog I001135) were purchased from Cyagen.”
Strain Description
The B6-hC3 mouse is a mouse C3 humanized model created by replacing the mouse C3 gene with the human C3 gene using gene-editing technology. The humanized regions include the 5’UTR and 3’UTR. Under natural breeding conditions, homozygous B6-hC3 mice exhibit mortality around 10 weeks of age, and it has been observed that heterozygous mice also experience mortality.
Application Area
Preclinical research on C3-targeted drugs
Research in immunotherapy, oncology, etc.
Validation Data