B6-hDPP4 (line1)
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hDPP4 (line1)
Product ID
I001187
Gene Name
Background
C57BL/6NCya
Gene Alias
CD26; ADABP; ADCP2; DPPIV; TP103
Classification
Other Target Humanized Models,Metabolic Target Humanized Models,Metabolic Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hDPP4 (line1) mice (Catalog I001187) were purchased from Cyagen.”
Strain Description
The B6-hDPP4 (line 1) mouse is a humanized model constructed by gene editing technology to replace a partial region of the mouse Dpp4 gene with the human DPP4 gene CDS sequence. This model can be used to study the infection mechanisms of viruses such as MERS-CoV and COVID-19, as well as to develop related virus vaccines. Additionally, this model can be utilized to develop DPP4 inhibitor therapies. Additionally, Cyagen Biosciences has developed B6-hDPP4(line 2) mice (Catalog ID: I001188) on the C57BL/6JCya background strain and BALB/c-hDPP4 (line 2) mice (Catalog ID: I001189) on the BALB/cAnCya background strain. These two models replace the mouse Dpp4 gene p.S29 to part of intron 2 with the Human DPP4 CDS (aa.29-766)-rBG pA expression cassette, meeting the experimental needs for different strain backgrounds.
Application Area
Development of DPP4 inhibitor therapies
Research on Middle East Respiratory Syndrome (MERS-CoV) infection
Research on Severe Acute Respiratory Syndrome (SARS-CoV) infection
Validation Data