B6-hDPP4 (line 2)
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Age
Genotype
Sex
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Basic Information
Model Name
B6-hDPP4 (line 2)
Product ID
I001188
Gene Name
Background
C57BL/6JCya
Gene Alias
CD26; ADABP; ADCP2; DPPIV; TP103
Classification
Other Target Humanized Models,Metabolic Target Humanized Models,Metabolic Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hDPP4 (line 2) mice (Catalog I001188) were purchased from Cyagen.”
Strain Description
The B6-hDPP4 (line 2) mouse is a humanized model constructed by gene editing technology to replace a partial region of the mouse Dpp4 gene with the human DPP4 gene CDS sequence. This model can be used to study the infection mechanisms of viruses such as MERS-CoV and COVID-19, as well as to develop related virus vaccines. Additionally, this model can be utilized to develop DPP4 inhibitor therapies. Similar models include the B6-hDPP4(line 1) mouse (Catalog ID: I001187), constructed on the C57BL/6NCya background strain, which replaces the sequence encoding aa.29~aa.760 of the mouse Dpp4 gene with the human DPP4 gene CDS sequence (aa.29-766), and the BALB/c-hDPP4 (line 2) mouse (Catalog ID: I001189), constructed on the BALB/cAnCya background strain. These models meet the experimental needs of different strain backgrounds.
Application Area
Development of DPP4 inhibitor therapies
Research on Middle East Respiratory Syndrome (MERS-CoV) infection
Research on Severe Acute Respiratory Syndrome (SARS-CoV) infection
Validation Data