A129 (Ifnar1 KO)
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Basic Information
Model Name
A129 (Ifnar1 KO)
Product ID
I001199
Gene Name
Background
129S2/SvPasCya
Gene Alias
Ifar; Ifrc; Ifnar; Infar
Classification
Immunodeficient Mouse Models,Autoimmune Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
16
Document
Note: When using this mouse strain in a publication, please cite “A129 (Ifnar1 KO) mice (Catalog I001199) were purchased from Cyagen.”
Strain Description
The A129 (Ifnar1 KO) mice on a 129 background are a type I (α/β) interferon receptor (Ifnar1) gene knockout model. The absence of the IFNAR1 protein in these mice leads to a lack of type I IFN receptor function, thereby reducing immune response and increasing susceptibility to viral infections. Homozygous A129 (Ifnar1 KO) mice are viable and fertile, but they show increased susceptibility to arbovirus infections.
Application Area
Investigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV
Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
Validation Data