Ndufs4 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Ndufs4 KO
Product ID
I001206
Gene Name
Background
C57BL/6JCya
Gene Alias
C1-18k; 6720411N02Rik
Classification
Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
13
Document
Note: When using this mouse strain in a publication, please cite “Ndufs4 KO mice (Catalog I001206) were purchased from Cyagen.”
Strain Description
The Ndufs4 KO mouse is a gene knockout model created using gene-editing techniques to knock out the Exon 2 of the Ndufs4 gene (the homolog of the human NDUFS4 gene) in mice. Homozygous Ndufs4 KO mice begin to exhibit phenotypes around 3 weeks of age, rendering them unable to breed offspring. This model can be used to study the pathogenic mechanisms of Leigh Syndrome, Leber's hereditary optic neuropathy (LHON), mitochondrial encephalomyopathy, lactic acidosis, and stroke (MELAS), and some forms of Parkinson's disease, providing a research basis for developing related therapeutic interventions.
Application Area
Research on Leigh Syndrome
Research on Leber's hereditary optic neuropathy (LHON)
Research on mitochondrial encephalomyopathy, lactic acidosis, and stroke (MELAS)
Research on some forms of Parkinson's disease
Validation Data