B6-hABCA4*c.5461-10T>C
Product Type
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Genotype
Sex
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Basic Information
Model Name
B6-hABCA4*c.5461-10T>C
Product ID
I001210
Gene Name
Background
C57BL/6JCya
Gene Alias
FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “B6-hABCA4*c.5461-10T>C mice (Catalog I001210) were purchased from Cyagen.”
Strain Description
The B6-hABCA4*c.5461-10T>C mouse is a humanized model of the Abca4 gene, where the mouse Abca4 gene has been replaced with the human ABCA4 gene carrying the c.5461-10T>C mutation using gene editing technology. This model can be used for research on various retinal degeneration diseases such as Stargardt disease (STGD), cone-rod dystrophy (CRD), and retinitis pigmentosa (RP).
Application Area
Research on Stargardt Disease (STGD)
Research on Cone-rod Dystrophy (CRD)
Research on Retinitis Pigmentosa (RP)
Validation Data