Applications for KO Mice
|
Target discovery and target confirmation Data from in vitro experiments are not reliable enough on their own; in vivo data is required to validate the target for a successful drug development program. KO mice mimic the activity of 100% effective antagonists. Use our available lines as tools for fast evaluation of your target. |
|
|
In vivo compound specificity Non-specific drugs may cause dangerous off-target effects, which are the primary cause of drug failures. Evaluating drug activity on similar targets (same family) or non-related targets can significantly de-risk a promising compound. KO models can remove a functional protein target, providing an in vivo system to detect potential off-target effects of an antagonist. |
|
|
Clinical studies Investigate physiological responses that may occur in patients during clinical trials, deepen your understanding of the physiological role of your target, and provide rapid answer to agencies' questions about the in vivo pathology related to your target. |
|
