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Custom Models
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- ● Diet-Induced Obesity (DIO) Mouse Model
- ● Type 1 Diabetes Mellitus (T1DM) Mouse Model
- ● Type 2 Diabetes Mellitus (T2DM) Mouse Model
- ● Diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Chemically Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model (Gene-editing)
- ● Composite (Combined) Model - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Model
- ● Composite Model - Atherosclerosis Mouse Model
- ● Atherosclerosis Mouse Model (Gene-editing)
- ● Acute Pancreatitis Mouse Model
- ● Chronic Pancreatitis Mouse Model
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Testimonials
"I've been very happy with Cyagen's service so I've been referring a lot of colleagues... thanks for
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great service."
'- Washington University in St. Louis
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Citations
IMMUNITY 47:107 (2017) IF=22.845
You may also be interested in
The metabolic dysfunction-associated steatotic liver disease (MASLD) model is established by feeding animals with high-fat and high-sugar diets, leading to overnutrition – the excessive amounts of lipids, cholesterol, and/or carbohydrates in the food cannot be fully absorbed and utilized. This overnutrition results in lipids accumulation, further inflammatory changes, and fibrosis. This model is the most commonly used MASLD animal model for human MASLD research. Different diet-induced models vary in characteristics, as shown below:
| Model | Mouse Type | Obesity | Insulin Resistance (IR) | Dyslipidemia | Elevated Transaminase | Fatty Degeneration of Liver | Hepatic Fibrosis |
|---|---|---|---|---|---|---|---|
| High-fat Diet Model | Mouse | Y | Y | Y | Y | Y | - |
| Rat | Y | Y | Y | Y | Y | - | |
| High-sugar Diet Model | Mouse | - | Y | Y | N | Y | - |
| Rat | Y | Y | Y | N | Y | - | |
| High-fat & High-sugar Diet Model | Mouse | Y | Y | Y | Y | Y | Y |
| Rat | Y | Y | Y | Y | Y | Y | |
| Methionine & Choline Deficient Diet Model | Mouse | N | N | N | Y | Y | Y |
| Rat | N | N | N | Y | Y | Y |
Note: Y: Yes, N: No, (-): without report
Detection Items: Body weight, food intake, serum biochemical test (alanine aminotransferase, aspartate aminotransferase, serum total cholesterol, triglyceride content, etc.), pathological analysis of liver tissue (liver tissue H & E staining, oil red).
Cyagen can provide you with a variety of drug evaluation models along with phenotype analysis services – delivering reliable and expedient data reporting for your project.
Order Supporting Information
Please see below for supporting information related to Cyagen animal orders.
(https://www.cyagen.com/us/en/support/order-information.html)
Inquiries and Quote Requests
Request a quote now. Alternatively, you can always email animal-service@cyagen.com or call 888-599-3306 to inquire about our services or obtain a quote for your project.
Why work with Cyagen?
- 18 years' experience in custom animal model generation
- 78,000+ animal models generated and delivered worldwide
- 10,925 citations in SCI journals
- 3,000+ university and company partners
- 100% money-back guarantee option available for most services
- AAALAC-Accredited and OLAW Assured
