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Gcdh KO
Product ID:
C001594
Background:
C57BL/6JCya
Documents:
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Strain Description
This strain was developed by gene editing to knock out the mouse Gcdh gene (the homolog of human GCDH), resulting in significantly elevated GA levels in plasma, brain, and liver tissues. It recapitulates the typical biochemical features of GA1 and is an ideal model for studying GA1 pathogenesis, drug development, and GCDH function.
Application Area
Area
Functional studies of GCDH protein
Area
Investigation of GA1 pathogenesis
Area
Development, screening, and preclinical evaluation of therapeutic drugs for GA1
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