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Immunodeficient Mouse Models
Transform your preclinical studies with our validated immunodeficient mouse models, offering >90% PDX take rates and superior human cell engraftment. Save 6+ months in development time while ensuring FDA-compliant data for your oncology and immunology research.
Regulatory-Ready Documentation
Access complete GLP-compliant validation data supporting FDA/EMA submissions immediately.
Comprehensive Genetic Backgrounds
Choose from BALB/c, C57BL/6, or custom strain backgrounds for optimal compatibility.
Superior Engraftment Efficiency
Achieve consistent >90% PDX take rates across all validated immunodeficient strains.
Overview
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FAQs
Overview
Validated Immunodeficient Models for Advanced Preclinical Research
Our immunodeficient mouse models, developed through systematic Targeted Gene Editing engineering, demonstrate consistent immune cell depletion (T, B, NK) and validated xenograft compatibility. Each strain undergoes rigorous testing across multiple research applications, ensuring reproducible experimental outcomes.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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MouseAtlas Model Library
Search and access curated genetically engineered mouse strains
Oncology CRO Platform
End-to-end preclinical oncology support from models to IND data
Autoimmune & Inflammation CRO Platform
Advancing autoimmune drug discovery with models and efficacy data.
Rodent Breeding
Scalable colony expansion with full genotyping support
Cryopreservation & Recovery
Preserve and revive rodent strains on demand
Rodent Phenotyping
Full-spectrum analysis for rodents model
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Base Strain
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Catalog NumberNameBase StrainResearch ApplicationAction
C001740BRG-Cd47 KOBALB/cAnCyaOncology: Investigating the mechanisms underlying tumor growth and metastasis, and evaluating the efficacy of antitumor drugs；Immunology: Exploring the mechanisms of immune cell development and maturation, as well as the pathogenesis of immune diseases；Epidemiology: Examining the mechanisms of viral and bacterial infectious disease pathogenesis；Stem Cell Biology: Investigating the potential of human stem cell transplantation
C001197Rag1 KOC57BL/6NCyaUsed for transplantation of primary cells, hematoma cells, and other tumor types
C001324Rag2 KOC57BL/6JCyaUsed for transplantation of primary cells, hematoma cells, and other tumor types
C001268Ifnar1 KOC57BL/6NCyaAntiviral immune responses, as well as interferon stimulation and JAK-STAT signaling
I001125AG129 (IFNα/β/γR KO)129S2/SvPasCyaInvestigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV；Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
I001199A129 (Ifnar1 KO)129S2/SvPasCyaInvestigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV；Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
I001200G129 (Ifngr1 KO)129S2/SvPasCyaInvestigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV；Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
C001332B6-Tcra KOC57BL/6JCyaStudy of Immunological, inflammatory, and autoimmune diseases
C001213Il12a KOC57BL/6NCyaCardiovascular Disease Research；Autoimmune Disease Research；Infectious Disease Research；Immune Cells and Systems Research
C001214Il12rb1 KOC57BL/6NCyaImmune System-Related Research
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FAQs
Frequently Asked Questions (FAQs)
How is myeloid cell development characterized in Cyagen's models?
huNOG-EXL models (engineered with human GM-CSF/IL-3 transgenes) show robust myeloid differentiation, including functional macrophages and dendritic cells. This addresses a key limitation of standard NSG mice.
How consistent is T-cell development in HLA-transgenic models?
Cyagen’s HLA-transgenic models support thymic education of human T cells, enabling antigen-specific responses critical for immunotherapy research. While TCR diversity data isn’t shown here, these models are validated for functional T-cell development.
What is the immunodeficient phenotype stability beyond the F10 generation?
Cyagen’s C-NKG models maintain stable immunodeficiency across generations. Studies show 90% human hepatocyte engraftment with serum albumin levels exceeding 1 mg/mL by 8–12 weeks post-transplant, enabling serial transplantation and 500 million-fold expansion.
Can you provide flow cytometry data for human CD45+ engraftment in bone marrow vs. peripheral blood?
While specific Cyagen data isn’t shown here, third-party studies using NOG/NSG models demonstrate stable CD45+ engraftment. For example, irradiated NOGW mice show >80% human CD45+ cells in bone marrow by 12–16 weeks, with peripheral blood engraftment reaching 20–40%. Cyagen’s models exhibit comparable or superior performance due to optimized genetic backgrounds.
What is the residual leakiness of NK cells in your NOG models compared to NSG strains?
Cyagen’s C-NKG® mice (NOD/Shi-Prkdcscid Il2rg−/−) completely lack functional NK cells due to the IL2RG knockout. This eliminates residual NK activity seen in older NSG models, ensuring superior human immune cell engraftment without murine NK-mediated rejection interference.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
Scarlett Rouge
Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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