Immunodeficient Mice

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Immunodeficient mice refer to mice with defects or deletions in one or more immune components (B cells, T cells, NK cells, etc.) in the immune system due to congenital genetic mutations or artificial methods. With the continuous development of gene editing technology, an increasing number of immunodeficient mouse strains have been developed. Immunodeficient mouse models are widely used in oncology (such as tumor growth, metastasis, anti-tumor drug screening), immunology (such as immune cell development and proliferation mechanism, immune disease occurrence mechanism), epidemiology (such as the pathogenesis of viral/bacterial infectious diseases), stem cell biology (such as human stem cell transplantation) and other research fields. Among these models, severely immunodeficient mice can be efficiently engrafted (due to the lack of T, B and NK immune cells) with human hematopoietic stem cells (HSCs), human peripheral blood mononuclear cells (PBMCs), xenografts derived from human tumor cell lines (CDX), xenografts derived from patient tumor tissues (PDX) or other adult stem cells and tissues, which are widely used in the construction of humanized mice.

Cyagen's drug screening and evaluation mouse model platform can provide you with multiple types of immunodeficiency mouse models such as NKG, Rag1 knockout (KO), Rag2 KO, Tcra KO, etc., to assist in the research and development of new drugs.

Item Number	Model Name	Strain Background	Research and Applications
C001316	NKG	NOD/SCID	Oncology; Immunity; Autoimmune diseases; Immunotherapy vaccines; GvHD/transplantation; Safety assessment and other related studies
C001416	NKG B2m KO	NKG	Graft-versus-host disease (GvHD); The immune system; Hematopoietic system; Blood disease; Cell line-derived xenograft (CDX); Patient-derived xenograft (PDX). (Significantly delayed the onset of GvHD.)
C001498	NKG-H2-Ab1 KO	NKG	Establishment of humanized mouse models for the immune system; research on graft-versus-host disease (GvHD) in xenotransplantation; research on the immune system, hematopoietic system, and blood disorders; xenotransplantation of human cell lines (CDX), patient tumor tissue xenotransplantation (PDX), and drug screening and efficacy evaluation.
C001513	NKG-hIL15	NKG	Severe immunodeficiency second-generation mice, effectively reconstruct NK cells.
C001197	Rag1 KO	C57BL/6NCya	Research on immune system-related diseases; Establishment of tumor-bearing models; Immune system deficiency; Cancer; Toxicology and other related research
C001324	Rag2 KO	C57BL/6JCya	Research on immune system-related diseases; Establishment of tumor-bearing models; Immune system deficiency; Cancer; Toxicology and other related research
C001332	Tcra KO	C57BL/6JCya	Immunology; Inflammation; Autoimmunity research
C001342	B6J-Ighm Ighd-DKO	C57BL/6JCya	Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research
C001343	BALB/c-Ighm Ighd-DKO	BALB/c	Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research
C001340	B6-Ighm KO	C57BL/6JCya	Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research
C001341	BALB/c-Ighm KO	BALB/c	Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research
C001344	B6-Ighj KO	C57BL/6JCya	Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research
C001345	BALB/c-Ighj KO	BALB/c	Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research
C001436	BRG	Balb/c	Oncology; Immunology; Infectious Disease; Stem Cell Biology; and related research.
I001176	NKG-hIL6	NKG	Construction of humanized mouse models with an immune system; Research on the human immune system and hematopoietic system; Xenotransplantation of human cell lines (CDX) and drug screening and efficacy evaluation; Xenotransplantation of patient-derived tumor tissues (PDX) and drug screening and efficacy evaluation.
C001559	NKG-MHC I/II dKO	NKG	Highly effective in delaying the occurrence of GvHD (graft-versus-host disease)
C001550	B6-Igl KO	C57BL/6NCya	Lambda type B cell deficiency
I001125	AG129	129S2/SvPasCya	Research on the pathogenesis of arthropod-borne viruses such as Dengue virus (DENV), Zika virus (ZIKV), Yellow fever virus (YFV), and Chikungunya virus (CHIKV), as well as the development of preventive vaccines; studies on antiviral immune responses, interferon stimulation, and JAK-STAT signaling pathways.
C001215	Alox5 KO	C57BL/6JCya	Hematopoietic regulation research; pathological research on myeloid leukemia; research on the mechanisms of atherosclerosis; research on the regulation of immune and inflammatory responses; other hematological tumor research.
C001367	B6RG	C57BL/6JCya	Research related to immune system deficiencies, cancer, toxicology, and xenotransplantation.
C001374	B6-Il2rg KO	C57BL/6JCya	Oncology: research on tumor growth, metastasis, and screening of anti-tumor drugs; Immunology: research on the mechanisms of immune cell development and proliferation, and the pathogenesis of immune diseases; Infectious Diseases: research on the pathogenic mechanisms of viral and bacterial infections; Stem Cell Biology: research on human-derived stem cell transplantation.
I001126	FRG	C57BL/6JCya	Human liver regeneration and reconstruction, liver biology, and liver-related drug research.
IR1023	SDRG	SD	Immunodeficient rats with deficiencies in T cells, B cells, and NK cells.
I001199	A129 (Ifnar1 KO)	129S2/SvPasCya	Research on the pathogenesis of arthropod-borne viruses and the development of preventive vaccines, as well as antiviral immune responses.
I001200	G129 (Ifngr1 KO)	129S2/SvPasCya	Research on the pathogenesis of arthropod-borne viruses and the development of preventive vaccines, as well as antiviral immune responses.
I001175	*NKG-KitV831M**	NKG	Construction of humanized mouse models of the immune system; Research on the human immune system and hematopoietic system; Human cell line xenografts (CDX) for drug screening and efficacy evaluation; Patient-derived tumor xenografts (PDX) for drug screening and efficacy evaluation.
I001177	NKG-SGM3	NKG	Construction of humanized mouse models of the immune system; Research on the human immune system and hematopoietic system; Human cell line xenografts (CDX) for drug screening and efficacy evaluation; Patient-derived tumor xenografts (PDX) for drug screening and efficacy evaluation.
C001213	Il12a KO	C57BL/6NCya	Immune Cells and Systems Research, Autoimmune Disease Research
C001214	Il12rb1 KO	C57BL/6NCya	Immune System-Related Research
C001390	B6-IgG1 KO	C57BL/6JCya	IgG1 Deficiency Diseases
C001394	B6-IgA KO	C57BL/6JCya	Selective Immunoglobulin A (IgA) Deficiency

Cyagen can provide you with a variety of drug evaluation models along with phenotype analysis services – delivering reliable and expedient data reporting for your project.

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