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Metabolic Disease Models
Get reliable research insights with our thoroughly validated metabolic disease mouse models. From diabetes to cardiovascular conditions, our specialized platforms support your drug development goals with reproducible results.
High-Quality Phenotype Analysis
Detailed evaluation services for metabolic disorders. Ensures robust data for research outcomes.
Genetic Modification Options
Tailored gene-edited mouse models. ​Enhances accuracy in studying metabolic disorders.​
Diverse Metabolic Disease Models
Access a wide range of gene-edited mouse models tailored for metabolic diseases, including obesity, type 2 diabetes, and atherosclerosis.
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Overview
Metabolic Disease Models for Innovative Research
Explore over 15 gene-edited models and 1,500 knockout variants targeting metabolic disorders such as obesity and type 2 diabetes. Each model is rigorously validated, enabling focused investigations into metabolic pathways and expediting the development of effective therapeutic interventions.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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MouseAtlas Model Library
Search and access curated genetically engineered mouse strains
Cardiometabolic CRO Platform
IND-ready studies using genetic and induced disease models
Rodent Breeding
Scalable colony expansion with full genotyping support
Rodent Phenotyping
Full-spectrum analysis for rodents model
BAC Modification
Custom genomic edits with full validation and transgenic support
Cryopreservation & Recovery
Preserve and revive rodent strains on demand
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Model Selection Made Simple
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Catalog NumberNameBase StrainResearch ApplicationAction
C001207Trem2 KOC57BL/6NCyaResearch on the pathogenesis of neurodegenerative diseases;Studies on the impact of immune responses and inflammation on the nervous system;Screening and evaluation of potential drugs targeting Trem2 or its pathway;Research on the genetic mechanisms of diseases such as Nasu-Hakola disease;Studies on amyloid degeneration and tau protein pathology
C001507B6J-Apoe KOC57BL/6JCyaCardiovascular disease research: Hypercholesterolemia, hyperlipidemia, atherosclerosis, etc.;Body metabolism mechanism research: Fat and cholesterol metabolism;Neurodegenerative disease research: Alzheimer's disease
I001220B6-hPCSK9/Apoe KOC57BL/6CyaDevelopment, screening, and preclinical evaluation of PCSK9-targeted drugs;Research on metabolic diseases such as hyperlipidemia, stroke, coronary heart disease, familial hypercholesterolemia (FH), and other atherosclerotic cardiovascular diseases (ASCVD)
C001368Lep KO (ob/ob)C57BL/6JCyaThe Lep KO mice can be used for the study of type II diabetes, obesity diseases, endocrine defects, and other metabolic diseases
C001600B6-hINHBE/obC57BL/6NCya;C57BL/6JCyaResearch on the obesity and type II diabetes;Research on the metabolic diseases associated with improper fat distribution and storage;Development of human INHBE-targeted therapies
C001601B6-hGLP-1R/obC57BL/6NCya;C57BL/6JCyaInvestigation of the pathogenesis of obesity and type 2 diabetes;Development and screening of drugs for obesity and type 2 diabetes;Research on other metabolic diseases such as cardiovascular and myocardial diseases;Study of the neuroprotective effect in nervous system diseases
C001549DIO-B6-MC57BL/6CyaResearch on diet-induced obesity, diabetes, inflammation, fatty liver, and other metabolic disorders;Preclinical evaluation of anti-obesity drugs
C001392Ldlr KO (em)C57BL/6JCyaResearch on atherosclerosis, macular tumor and coronary artery disease, familial hypercholesterolemia (FHCL1), and other metabolic and cardiovascular diseases, and screening of vasodilator drugs.
C001232Uox KOC57BL/6JCyaHyperuricemia Research;Gout and Related Disease Research;Other Metabolic and Renal Disease Research
C001560Pah KOC57BL/6JCyaResearch on the genetic mechanism of phenylketonuria (PKU) and the preclinical evaluation of therapeutic drugs;Research related to protein metabolism, nervous system, pigmentation, etc.
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FAQs
Frequently Asked Questions (FAQs)
Does Cyagen offer customization options for specific metabolic pathways or receptor modifications that might be relevant to drug targets?
Yes, Cyagen offers customization options for specific metabolic pathways or receptor modifications tailored to individual research needs. Researchers can request specific genetic modifications that align with their drug targets, facilitating more relevant studies on drug efficacy and mechanisms of action related to those pathways.
What biomarker panels have been validated in Cyagen models, particularly for early-stage metabolic dysfunction detection?
Cyagen has validated several biomarker panels in their metabolic disease models for early detection of metabolic dysfunction. These panels include biomarkers associated with insulin sensitivity, lipid metabolism, and inflammatory responses, which are crucial for identifying early signs of metabolic disorders.
Have any published studies used Cyagen models for testing currently approved metabolic disease drugs, and if so, how did the efficacy results compare to known human clinical outcomes?
Yes, several studies have utilized Cyagen's models to test currently approved metabolic disease drugs. The efficacy results from these studies have been shown to correlate well with known human clinical outcomes, reinforcing the relevance of these animal models in preclinical drug testing.
Does Cyagen models exhibit the key comorbidities associated with metabolic syndrome (cardiovascular complications, hepatic steatosis, inflammation) that we typically see in human patients?
Yes, Cyagen's metabolic disease models exhibit key comorbidities associated with metabolic syndrome, including:
Cardiovascular Complications: Models designed to study atherosclerosis and cardiovascular diseases linked to metabolic disorders.
Hepatic Steatosis: Models reflect conditions like metabolic dysfunction-associated steatotic liver disease (MASLD), including inflammation and fibrosis.
Inflammation: Models incorporate inflammatory responses typical of metabolic syndrome, crucial for understanding liver-related complications.
These features make Cyagen's models valuable for studying the interactions of metabolic syndrome and its comorbidities.
What specific genetic modifications have been incorporated into Cyagen models to replicate the polygenic nature of human metabolic disorders?
Cyagen incorporates various genetic modifications in their mouse models to mimic the polygenic nature of human metabolic disorders. Examples include:
Ldlr KO (em): Used for studying familial hypercholesterolemia.
Lep KO (ob/ob): Models type 2 diabetes and obesity.
Uox KO: Relevant for hyperuricemia studies.
These modifications allow for the exploration of complex genetic interactions that contribute to conditions like obesity and diabetes.
What phenotypic validation data does Cyagen have demonstrating the stability of metabolic parameters (insulin resistance, glucose tolerance, lipid profiles) across different generations?
Cyagen's metabolic disease models consistently stabilize key metabolic parameters, such as insulin resistance, glucose tolerance, and lipid profiles, across different generations. This stability is validated through rigorous testing protocols that ensure reliable results for preclinical research and drug development.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
Scarlett Rouge
Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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