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- ● Diet-Induced Obesity (DIO) Mouse Model
- ● Type 1 Diabetes Mellitus (T1DM) Mouse Model
- ● Type 2 Diabetes Mellitus (T2DM) Mouse Model
- ● Diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Chemically Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model (Gene-editing)
- ● Composite (Combined) Model - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Model
- ● Composite Model - Atherosclerosis Mouse Model
- ● Atherosclerosis Mouse Model (Gene-editing)
- ● Acute Pancreatitis Mouse Model
- ● Chronic Pancreatitis Mouse Model
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huHSC-NKG-ProM Mice
Suitable for tumor immunology research related to human myeloid cells
The huHSC-NKG-ProM mice are an enhanced version of the huHSC-NKG series. The "Pro" indicates the upgraded series, while "M" stands for human myeloid cell reconstitution. This model can develop multiple human immune cells including T cells, B cells, and myeloid cells (dendritic cells and monocytes). This mouse model is suitable for tumor immunology research related to human myeloid cells.
Construction Process
Research Applications
- Tumor Immunology Research: Ideal for studying immune checkpoint inhibitors and drugs targeting human myeloid cells, such as PD-1 monoclonal antibodies in combination with agents that influence human macrophage polarization.
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Autoimmune Disease Research: Useful for evaluating the mechanisms underlying autoimmune disease onset and exploring potential therapeutic approaches.
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Drug Metabolism and Toxicity Research: Suitable for assessing the pharmacokinetic properties and toxicological effects of candidate compounds in vivo.
Validation data
Sample type: Peripheral Blood
1. Humanized Level Post Human HSC Transplantation in NKG Mice:
Human umbilical cord blood-derived HSCs are transplanted into NKG mice for immune system reconstitution, resulting in human CD45+ leukocyte to total CD45+ leukocyte ratio exceeding 30%.
2. Proportions of T Cells and B Cells Post Human HSC Transplantation in NKG Mice:
The T cell to human leukocyte ratio exceeds 20%, while the B cell to human leukocyte ratio ranges from 40 to60% from 14 weeks post-human HSC engraftment.
3. Proportions of NK cells Post Human HSC Transplantation in NKG:
The human NK cell to leukocyte ratio is below 5%, while the human monocyte to leukocyte ratio in peripheral blood is at 5-10%. Since macrophages primarily originate from monocytes, monocyte detection is mainly performed in peripheral blood samples.
4. Body Weight and Survival Rate Post Human HSC Transplantation in NKG:
