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Covid-19 Mouse Models
Accelerate vaccine, antiviral, and immunology studies with validated hACE2 mouse models engineered for translational relevance and rapid delivery.
Expert-Guided
Free tech consultation on model selection and experimental alignment in minute
Proven Relevance
Validated for SARS-CoV-2 infection and pathogenesis studies
Rapid Access
hACE2 models delivered in as fast as 1 month
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Overview
COVID-19 Mice Built for SARS-CoV-2 Research
Though modeling full disease heterogeneity remains complex, our diversified hACE2 mouse portfolio—featuring K18, ROSA26, and endogenous knock-ins—offers validated, flexible platforms for infection studies, immune profiling, and long-term complication analysis.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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MouseAtlas Model Library
Search and access curated genetically engineered mouse strains
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Scalable colony expansion with full genotyping support
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Full-spectrum analysis for rodents model
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Browse validated human KO cell lines by gene or cell type
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Full-spectrum analysis for rodents model
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AI-guided AAV design and full-spectrum preclinical validation
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Model Selection Made Simple
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Base Strain
Catalog Number
Catalog NumberNameBase StrainResearch ApplicationAction
I001125AG129 (IFNα/β/γR KO)129S2/SvPasCyaInvestigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV；Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
I001199A129 (Ifnar1 KO)129S2/SvPasCyaInvestigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV；Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
I001200G129 (Ifngr1 KO)129S2/SvPasCyaInvestigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV；Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
C001191hACE2-All CDS-B6JC57BL/6JCyaCOVID-19 and related diseases research；COVID-19 vaccine and antibody drug evaluation
C001227hACE2-All CDS-BALBCBALB/cAnCyaCOVID-19 and related diseases research；COVID-19 vaccine and antibody drug evaluation
C001226hACE2-EGFPC57BL/6NCyaCardiovascular function research；SARS-CoV-2 infection mechanism research；SARS-CoV-2 vaccine development evaluation；SARS-CoV-2 prevention and treatment drug screening evaluation；SARS-CoV-2 antibody drug development validation
C001246ROSA26-LSL-hACE2C57BL/6JCyaCardiovascular function research；SARS-CoV-2 infection mechanism research；SARS-CoV-2 vaccine development evaluation；SARS-CoV-2 prevention and treatment drug screening evaluation；SARS-CoV-2 antibody drug development validation
C001281loxP-hACE2-CDStmC57BL/6NCyaCardiovascular function research；SARS-CoV-2 infection mechanism research；SARS-CoV-2 vaccine development evaluation；SARS-CoV-2 prevention and treatment drug screening evaluation；SARS-CoV-2 antibody drug development validation
C001228Ace2 KOC57BL/6JCyaResearch on Cardiovascular and Cardiac Contraction；Research on Renal Function and Colitis；Research on COVID-19 and SARS
C001244K18-hACE2-2A-CreERT2C57BL/6JCyaCOVID-19 and related diseases research；COVID-19 vaccine and antibody drug evaluation
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FAQs
Frequently Asked Questions (FAQs)
What is the typical lead time for catalog versus custom COVID-19 mouse models from Cyagen?
Cyagen strives to provide timely delivery of its mouse models:
Catalog Models: Available for immediate shipment or within a few weeks, depending on stock availability.


Custom Models: Delivery timelines vary based on the complexity of the genetic modifications but are typically completed within 3 to 6 months.


For specific timelines and availability, please contact our support team.
Can Cyagen’s models be used to study long-term outcomes or post-viral syndromes like long COVID?
Yes, certain Cyagen hACE2 mouse models are suitable for studying long-term effects of SARS-CoV-2 infection:
The K18-hACE2 model has been used to investigate neurological complications and other long-term sequelae associated with COVID-19.


These models facilitate research into the mechanisms underlying long COVID and the development of potential therapeutic interventions.
How does Cyagen ensure genetic consistency and minimize variability across animal cohorts?
Cyagen maintains rigorous quality control measures to ensure genetic consistency:
All mouse models are generated and maintained under specific pathogen-free (SPF) conditions.


Genetic backgrounds are standardized, with many models available on pure C57BL/6J or BALB/c strains.


Regular genotyping and phenotypic assessments are conducted to confirm model integrity.


These practices minimize variability and ensure reproducibility in experimental outcomes.
Are inducible or conditional hACE2 models available for tissue- or time-specific infection studies?
Yes, Cyagen offers inducible and conditional hACE2 mouse models:
K18-hACE2-2A-CreERT2 Mice: Combine hACE2 expression with a tamoxifen-inducible Cre recombinase, allowing temporal control over gene expression. This model is ideal for studying the effects of SARS-CoV-2 infection at specific developmental stages or time points.


ROSA26-LSL-hACE2 Mice: Enable tissue-specific expression of hACE2 when bred with mice expressing Cre recombinase under tissue-specific promoters, facilitating targeted studies of organ-specific infection and pathology.
What validation data does Cyagen provide to support the use of its models in SARS-CoV-2 pathogenesis studies?
Cyagen provides comprehensive validation data for its hACE2 mouse models, including:
Confirmation of hACE2 expression levels and tissue distribution.


Data on susceptibility to SARS-CoV-2 infection, including viral load measurements in various organs.


Histopathological analyses demonstrating disease progression and tissue damage post-infection.


These data sets are available upon request to support your research planning.
How do Cyagen’s hACE2 mouse models differ in terms of viral tropism and tissue-specific expression?
Cyagen offers a diverse portfolio of hACE2 mouse models with varying expression patterns:
K18-hACE2 Mice: Express human ACE2 under the human keratin 18 promoter, leading to high expression in epithelial tissues, including the lungs and brain. This model is suitable for studying severe COVID-19 manifestations and neuroinvasion.


hACE2-All CDS-B6J Mice: Feature human ACE2 expression driven by the mouse's endogenous Ace2 regulatory elements, resulting in physiological expression patterns across multiple tissues.


ROSA26-LSL-hACE2 Mice: Contain a loxP-STOP-loxP cassette allowing for tissue-specific expression of hACE2 when crossed with Cre-expressing lines, enabling targeted studies of SARS-CoV-2 infection in specific organs.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
Scarlett Rouge
Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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